KIF3A Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5121019-Each-of-1 | In Stock | ₹ 44,811.50 |
PIPA5121019 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,811.50
GST (18%): ₹ 8,066.07
Total Price: ₹ 52,877.57
Antigen
KIF3A
Classification
Polyclonal
Conjugate
Unconjugated
Gene
KIF3A
Gene Alias
fc55h04; FLA10; hypothetical protein LOC550267; Kif3; KIF3A; Kifl; kinesin family member 3a; kinesin family protein 3A; kinesin-II subunit; kinesin-like protein KIF3A; Kinesin-like protein KIF3A-like protein; KLP-20; Kns3; microtubule plus end-directed kinesin motor 3A; N-4 kinesin; Unknown (protein for IMAGE:7984856); wu:fc55h04; zgc:110284; zgc:110284 protein
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
11127, 16568, 84392
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
2.38 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
P28741, Q9Y496
Gene Symbols
KIF3A
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 430-699 of human KIF3A (NP_008985.3).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive test controls include: MCF-7, SW480, 293T, SKOV3, HeLa, Mouse brain, Mouse ovary, Rat liver, Rat brain
- The target is usually found in the following locations: Cell projection, Cytoplasm, cilium, cytoskeleton
- Immunogen sequence: RKALETKLDM EEEERNKARA ELEKREKDLL KAQQEHQSLL EKLSALEKKV IVGGVDLLAK AEEQEKLLEE SNMELEERRK RAEQLRRELE EKEQERLDIE EKYTSLQEEA QGKTKKLKKV WTMLMAAKSE MADLQQEHQR EIEGLLENIR QLSRELRLQM LIIDNFIPRD YQEMIENYVH WNEDIGEWQL KCVAYTGNNM RKQTPVPDKK EKDPFEVDLS HVYLAYTEES LRQSLMKLER PRTSKGKARP KTGRRKRSAK PETVIDSLLQ The kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell
- Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis
- Members of the heterotrimeric kinesin II family of microtubule associated motors generally contain two different motor subunits from the KIF3 family, which includes KIF3A, B and C
- KIF3 isoforms mediate anterograde transport of membrane bound organelles in neurons and melanosomes, transport between the endoplasmic reticulum and the Golgi, and transport of protein complexes within cilia and flagella required for their morphogenesis
- KIF3A may influence neurogenesis at the level of embryonic cellular events, where the asymmetry of the genetic control circuit controlling left-right (L-R) axis determination is defined
- Loss of KIF3A function in mice photoreceptors causes apoptotic cell death, suggesting that kinesin II mediated transport is required for proper cell fate.