HGS Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA595931-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA595931 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
HGS
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HGS
Gene Alias
hepatocyte growth factor-regulated tyrosine kinase substrate, HGF-regulated tyrosine kinase substrate, HGNC:4897, Hgr, Hgs, Hrs, Hrs2, human growth factor-regulated tyrosine kinase substrate, protein pp110, SNAP-25-interacting protein Hrs-2, ZFYVE8
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
15239, 56084, 9146
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Concentration
0.11 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
O14964, Q99LI8, Q9JJ50
Gene Symbols
HGS
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 548-777 of human HGS (NP_0047031)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: EQQKQTVQMR AQMPAFPLPY AQLQAMPAAG GVLYQPSGPA SFPSTFSPAG SVEGSPMHGV YMSQPAPAAG PYPSMPSTAA DPSMVSAYMY PAGATGAQAA PQAQAGPTAS PAYSSYQPTP TAGYQNVASQ APQSLPAISQ PPQSSTMGYM GSQSVSMGYQ PYNMQNLMTT LPSQDASLPP QQPYIAGQQP MYQQMAPSGG PPQQQPPVAQ QPQAQGPPAQ GSEAQLISFD; Positive Samples: THP-1, OVCAR3, MCF7, HepG2, Mouse testis, Rat testis; Cellular Location: Cytoplasm, Cytoplasmic side, Early endosome membrane, Endosome, Peripheral membrane protein, multivesicular body membrane HGS is involved in intracellular signal transduction mediated by cytokines and growth factors
- When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF
- It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin
- HGS may concentrate ubiquitinated receptors within clathrin-coated regions
- It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM
- This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes
- HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.