PIPA5121738
NOTCH2NL Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5121738-Each-of-1 | In Stock | ₹ 19,669.00 |
PIPA5121738 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 19,669.00
GST (18%): ₹ 3,540.42
Total Price: ₹ 23,209.42
Antigen
NOTCH2NL
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NOTCH2NL
Gene Alias
N2N; notch 2 N-terminal like; Notch homolog 2 N-terminal like protein; notch homolog 2 N-terminal-like protein; Notch homolog 2 N-terminal-like protein A; Notch homolog 2 N-terminal-like protein C; NOTCH2NL; NOTCH2NLA; NOTCH2NLC
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
388677
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300
Gene Accession No.
Q7Z3S9
Gene Symbols
NOTCH2NL
Immunogen
Recombinant protein Notch2 N-Terminal Like Protein
Quantity
20 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261)
- Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954)
- Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954)
- Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954)
- Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation
- [UniProt]