PIPA5121739

NOSIP Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA5121739-Each-of-1 In Stock ₹ 14,756.20

PIPA5121739 - Each of 1

₹ 14,756.20

In Stock

Quantity

1

Base Price: ₹ 14,756.20

GST (18%): ₹ 2,656.116

Total Price: ₹ 17,412.316

Antigen

NOSIP

Classification

Polyclonal

Conjugate

Unconjugated

Gene

NOSIP

Gene Alias

2310061K06Rik; CGI-25; E3 ubiquitin-protein ligase NOSIP; eNOS-interacting protein; nitric oxide synthase interacting protein; nitric oxide synthase-interacting protein; Nosip; RING-type E3 ubiquitin transferase NOSIP

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

51070

Content And Storage

-20°C

Form

Liquid

Applications

Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration

500 μg/mL

Formulation

PBS with 50% glycerol and 0.05% ProClin 300

Gene Accession No.

Q9Y314

Gene Symbols

NOSIP

Immunogen

Recombinant protein Nitric Oxide Synthase Interacting Protein. The antigen corresponds to amino acid range 62-295 of the target protein.

Quantity

20 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

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Description

  • NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates
  • NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation
  • NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1
  • 2, Nav1
  • 3, Nav1
  • 5, Nav1
  • 7, Nav1
  • 8, Kv1
  • 3, EAAT1 or CLC5
  • NEDD4L also promotes ubiquitination and degradation of SGK.