DNase I Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5122030-Each-of-1 | In Stock | ₹ 14,756.20 |
PIPA5122030 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 14,756.20
GST (18%): ₹ 2,656.116
Total Price: ₹ 17,412.316
Antigen
DNase I
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DNASE1
Gene Alias
AI788650; deoxyribonuclease; Deoxyribonuclease 1; deoxyribonuclease I; Deoxyribonuclease1; Deoxyribonuclease-1; DeoxyribonucleaseI; DNASE 1; DNase I; DNase I lysosomal; DNase I, lysosomal; Dnase1; DNaseI; DNL 1; DNL1; Dornase alfa; DRNI; epithelial lens deoxyribonuclease I; FLJ38093; human urine deoxyribonuclease I; pancreatic deoxyribonuclease I
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1773
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300
Gene Accession No.
P24855
Gene Symbols
DNASE1
Immunogen
Recombinant protein Deoxyribonuclease I. The antigen corresponds to amino acid range 19-259 of the target protein.
Quantity
20 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Internucleosomal DNA fragmentation following the activation of endonucleases is the common end point of apoptosis
- DNase I, a Ca2+/Mg2+-dependent endonuclease ubiquitously expressed in mammalian tissues, has been implicated to mediate internucleosomal DNA degradation in human cells undergoing apoptosis
- DNase I is highly polymorphic, and at least six alleles of DNase I are known
- DNase II, the ubiquitously expressed acidic deoxyribonuclease, acts downstream of caspase activation and may also induce DNA digestion during apoptosis
- DNase I cleaves DNA to 5'-phosphodinucleotide and 5'-phospho- oligonucleotide end-products, whereas DNase II cleaves DNA to 3'-phosphomononucleotide and 3'-phosphooligonucleotide end-products
- The mechanism by which DNase II cuts DNA is similar to DNase I, which produces nicks rather than double-strand cuts
- DNase II is usually present in cytoplasm of epithelial cells, but it appears concentrated in the nuclei of lens fibers
- In contrast, DNase I is always concentrated in nuclei of epithelial and fiber cells.