PIPA5122105
CDK4 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5122105-Each-of-1 | In Stock | ₹ 14,756.20 |
PIPA5122105 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 14,756.20
GST (18%): ₹ 2,656.116
Total Price: ₹ 17,412.316
Antigen
CDK4
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Cdk4
Gene Alias
Cdk4; Cell division protein kinase 4; CMM3; Crk3; cyclin dependent kinase 4; cyclin-dependent kinase 4; MGC14458; p34<PSK-J3>/cdk4; PSK-J3; serine/threonine kinase; Unknown (protein for MGC:133903)
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1019
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300
Gene Accession No.
P11802
Gene Symbols
Cdk4
Immunogen
Recombinant protein Cyclin Dependent Kinase 4. The antigen corresponds to amino acid range 6-295 of the target protein.
Quantity
20 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex
- CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle
- CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2)
- CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex
- CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins
- SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2
- Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.