PIPA5142021
TAB182 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5142021-Each-of-1 | In Stock | ₹ 40,317.00 |
PIPA5142021 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,317.00
GST (18%): ₹ 7,257.06
Total Price: ₹ 47,574.06
Antigen
TAB182
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TNKS1BP1
Gene Alias
182 kDa tankyrase-1-binding protein; KIAA1741; TAB182; tankyrase 1 binding protein 1; tankyrase 1 binding protein 1, 182kDa; tankyrase 1-binding protein of 182 kDa; testis secretory sperm-binding protein Li 206a; TNKS1BP1
Host Species
Goat
Purification Method
Ammonium sulfate precipitation
Regulatory Status
RUO
Gene ID (Entrez)
85456
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
Immunohistochemistry (Paraffin)
Concentration
0.5 mg/mL
Formulation
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q9C0C2
Gene Symbols
TNKS1BP1
Immunogen
Peptide with sequence KVSTLRESSAMAS-C.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Related Products
Description
- This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000
- Preliminary analysis showed no signal in Western Blot
- TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins
- Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor)
- Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation
- TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain
- This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres
- TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.