PIPA5142176
TIN2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5142176-Each-of-1 | In Stock | ₹ 40,317.00 |
PIPA5142176 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,317.00
GST (18%): ₹ 7,257.06
Total Price: ₹ 47,574.06
Antigen
TIN2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Tinf2
Gene Alias
AW552114; D14Wsu146e; DKCA3; TERF1 (TRF1)-interacting nuclear factor 2; TERF1 interacting nuclear factor 2; TERF1-interacting nuclear factor 2; tin; TIN2; Tin-2; TINF2; TRF1-interacting nuclear factor 2; TRF1-interacting nuclear protein 2
Host Species
Goat
Purification Method
Ammonium sulfate precipitation
Regulatory Status
RUO
Gene ID (Entrez)
26277
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
Immunohistochemistry (Paraffin)
Concentration
0.5 mg/mL
Formulation
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q9BSI4
Gene Symbols
Tinf2
Immunogen
Peptide with sequence C-KENPVDLPATEQKE.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Related Products
Description
- This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:1,000
- TRF1 is a negative regulator of telomere length maintenance
- Recently two proteins, tankyrase and Tin2, which bind to mammalian TRF1, have been identified
- Tankyrase is a protein with homology to ankyrins as well as to the catalytic domain of poly (adenosine diphosphate-ribose) polymerase (PARP)
- Tankyrase localizes to telomeres by binding to the telomeric repeat binding factor 1 (TRF1) through its ankyrin repeats
- Tankyrase exhibits PARP activity functioning as acceptors for adenosine diphosphate (ADP)-ribosylation
- Since ADP-ribosylation of TRF1 diminishes its ability to bind to telomeric DNA, this suggests that telomere function in human cells is regulated by poly (ADP)-ribosylation
- Both the cell cycle and TRF1 may regulate the subcellular localization of tankyrase
- The cDNA coding for TIN2 protein was isolated as interacting partner of TRF1 from a yeast two-hybrid cDNA library screening
- Tin2 localizes to telomeres and is essential for proper regulation of telomere length
- TIN2, like TRF1, is widely and constitutively expressed, suggesting that these proteins act together to counterbalance telomere elongation by telomerase
- However, endogenous TIN2, like endogenousTRF1, is not highly expressed, and therefore may be difficult to visualize by immunostaining in certain cell systems.