B7-H4 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5142841-Each-of-1 | In Stock | ₹ 40,317.00 |
PIPA5142841 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,317.00
GST (18%): ₹ 7,257.06
Total Price: ₹ 47,574.06
Antigen
B7-H4
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Vtcn1
Gene Alias
B7 family member, H4; B7 homolog 4; B7 superfamily member 1; B7h.5; B7H4; B7-H4; B7s1; B7x; BC032925; EMBL:AAH95842.1}; FLJ22418; immune costimulatory protein B7-H4; PRO1291; Protein B7S1; RGD1311204; RP11-229A19.4; t cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; UNQ659/PRO1291; VCTN1; V-set domain containing T cell activation inhibitor 1; V-set domain containing T-cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; Vtcn1; vtcn1 {ECO:0000312
Host Species
Goat
Purification Method
Ammonium sulfate precipitation
Regulatory Status
RUO
Gene ID (Entrez)
79679
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
Western Blot
Concentration
0.5 mg/mL
Formulation
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q7Z7D3
Gene Symbols
Vtcn1
Immunogen
Peptide with sequence C-PEVNVDYNASSET.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Related Products
Description
- This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000
- B7-H4 (B7x, VTCN1) a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity
- Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production
- B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response
- B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells
- Aberrant expression has been associated with cancers of the lung, breast and ovary in humans
- B7-H4 is expressed primarily on the membrane of lymphoid cells, and as an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, it is involved in mediating cellular and humoral immune responses
- Overexpression of B7-H4 is associated with certain malignancies, including ovarian and breast cancer, which may be a mechanism by which tumor cells suppress T cell immunity and facilitate tumor progression
- Further, VTCN1 may be a useful biomarker for the early detection of ovarian cancer and Renal Cell Carcinoma (RCC).