Zika Virus NS3 (strain H/PF/2013) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5143436-Each-of-1 | In Stock | ₹ 39,071.00 |
PIPA5143436 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,071.00
GST (18%): ₹ 7,032.78
Total Price: ₹ 46,103.78
Antigen
Zika Virus NS3 (strain H/PF/2013)
Classification
Polyclonal
Conjugate
Unconjugated
Gene Alias
NS3 protease; Zika NS3 protease; Zika Virus NS3 protease
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of Zika virus NS3 protein (Zika virus (strain H/PF/2013)). The exact sequence is proprietary.
Quantity
100 μL
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 20% glycerol and 0.025% Proclin 300; pH 7
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Target Species
Virus
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Store as concentrated solution
- Centrifuge briefly prior to opening vial
- Zika virus is a flavivirus discovered in 1947, but the association between Zika virus infection and brain disorders was not demonstrated until 2015 in Brazil
- Infection mostly poses a threat to women during pregnancy, since it may cause microcephaly and other neurological dysfunctions in the developing fetus
- ZIKV NS3 expression alone may induce BMP2 maturation, osteogenic gene expression and calcification, but purified NS3 protease has been reported to effectively cleave pro-BMP2 in vitro to generate biologically active mature BMP2
- These findings highlight ZIKV-induced calcification where the NS3 protease subverts the BMP2-mediated osteogenic signalling pathway to trigger brain calcification
- The nonstructural NS3 protein is essential for virus replication because it helps to remodel the cellular microenvironment
- Several reports show that this protease can process cellular substrates and thereby modify cellular pathways that are important for the virus.