Nova-2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5144011-Each-of-1 | In Stock | ₹ 35,422.00 |
PIPA5144011 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 35,422.00
GST (18%): ₹ 6,375.96
Total Price: ₹ 41,797.96
Antigen
Nova-2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NOVA2
Gene Alias
ANOVA; astrocytic NOVA1-like RNA-binding protein; Gm1424; neuro-oncological ventral antigen 2; neuro-oncological ventral antigen 3; NOVA alternative splicing regulator 2; NOVA2; NOVA3; RNA-binding protein Nova-2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
292681, 384569, 4858
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Applications
ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Concentration
500 μg/mL
Formulation
PBS with 4MG trehalose and 0.05MG sodium azide
Gene Accession No.
Q9UNW9
Gene Symbols
NOVA2
Immunogen
E.coli-derived human NOVA2 recombinant protein (Position: M1-Q205).
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Lyophilized
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Description
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
- Paraneoplastic opsoclonus myoclonus ataxia (POMA) is a neurologic disorder thought to be mediated by an autoimmune attack against onconeural disease antigens that are expressed by gynecologic or lung tumors and by neurons
- Nova-1 and -2 are both POMA disease antigens
- The autoimmune attack against Nova-2 in POMA patients results in latent cancer, reduced inhibitory control of movements, and dementia
- Nova-2 is closely related to Nova-1, and is expressed at high levels in neurons during development and at lower levels in the adult lung
- In the postnatal mouse brain, Nova-2 is expressed in a pattern that is largely reciprocal with Nova-1, including high levels of Nova-2 expression in the neocortex and hippocampus
- Both Novas are RNA binding proteins, and Nova-2 binds RNA with high affinity and with sequence specificity that differs from Nova-1
- They regulate neuronal pre-messenger RNA splicing by directly binding to RNA
- Nova-2 target genes function either in the synapse or in axon guidance indicating that Nova-2 is a major regulator of synaptic function.