ACK1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA514765-Each-of-1 | In Stock | ₹ 46,591.50 |
PIPA514765 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,591.50
GST (18%): ₹ 8,386.47
Total Price: ₹ 54,977.97
Antigen
ACK1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TNK2
Gene Alias
ACK; ACK1; Ack-1; Activated CDC42 kinase 1; activated Cdc42-associated kinase 1; activated p21cdc42Hs kinase; Cdc42 GTPase-inhibiting protein; Cdgip; Non-receptor protein tyrosine kinase Ack; p21cdc42Hs; P21cdc42Hs kinase; Pyk1; Tnk2; tnk2 {ECO:0000250; tyrosine kinase non receptor 2; tyrosine kinase non-receptor protein 2; tyrosine kinase, non-receptor, 2; UniProtKB:Q07912}
Host Species
Rabbit
Purification Method
Antigen affinity chromatography, Protein A
Regulatory Status
RUO
Gene ID (Entrez)
10188, 51789
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
O54967, Q07912
Gene Symbols
TNK2
Immunogen
KLH conjugated synthetic peptide between 934-964 amino acids from the C-terminal region of human ACK1
Quantity
400 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- This antibody is predicted to react with bovine based on sequence homology
- TNK2 (ACK) (activated Cdc42-associated kinase) is a non-receptor tyrosine kinase that signals downstream of Cdc42
- TNK2 is known to be involved in tumorigenesis and metastasis, particularly in prostate cancer
- Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1
- May be involved both in adult synaptic function and plasticity and in brain development
- Activates AKT1 by phosphorylating it on 'Tyr-176'
- Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs)
- Phosphorylates WWOX on 'Tyr-287'
- Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins
- Contributes to the control of AXL receptor levels
- Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR
- Phosphorylates WASP.