TDP-43 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA517011-Each-of-1 | In Stock | ₹ 52,688.00 |
PIPA517011 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,688.00
GST (18%): ₹ 9,483.84
Total Price: ₹ 62,171.84
Antigen
TDP-43
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TARDBP
Gene Alias
1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
230908, 23435, 298648
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Concentration
14 μg/mL
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.
Q13148, Q921F2
Gene Symbols
TARDBP
Immunogen
Synthetic peptide corresponding to residues surrounding Gly400 of human TDP43
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- It is not recommended to aliquot this antibody
- TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR
- Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"ee; splice site
- A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U)
- TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.