TBK1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA517478-Each-of-1 | In Stock | ₹ 52,688.00 |
PIPA517478 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,688.00
GST (18%): ₹ 9,483.84
Total Price: ₹ 62,171.84
Antigen
TBK1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TBK1
Gene Alias
1200008B05Rik; AI462036; AW048562; FLJ11330; FTDALS4; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine protein kinase TBK1; serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1; TANK-binding kinase 1; tbk; TBK1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
29110, 299827, 56480
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Concentration
174 μg/mL
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.
Q9UHD2, Q9WUN2
Gene Symbols
TBK1
Immunogen
Synthetic peptide corresponding to residues near the carboxy-terminus of TBK1/NAK
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- It is not recommended to aliquot this antibody
- TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling
- TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses
- NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli
- NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity
- Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB
- The IKK complex contains IKKa, IKK beta, and IKKK
- A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K
- NAK/TBK1 activates IKK beta through direct phosphorylation
- NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors
- NAK/TBK1 functions upstream of NIK and the IKK complex
- NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.