Survivin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA517520-Each-of-1 | In Stock | ₹ 51,397.50 |
PIPA517520 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 51,397.50
GST (18%): ₹ 9,251.55
Total Price: ₹ 60,649.05
Antigen
Survivin
Classification
Polyclonal
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.
O15392
Gene Symbols
Birc5
Immunogen
Synthetic peptide corresponding to residues near the carboxyl terminus of human survivin
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Gene
Birc5
Gene Alias
AAC-11; AP14; Api4; apoptosis inhibitor 4; Apoptosis inhibitor survivin; baculoviral IAP repeat containing 5; baculoviral IAP repeat-containing 5; baculoviral IAP repeat-containing 5 (survivin); baculoviral IAP repeat-containing protein 5; BIRC 5; BIRC5; EPR 1; EPR-1; Iap4; inhibitor of apoptosis; survivin; survivin variant 3 alpha; survivin40; SVV; TIAP
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
332
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- It is not recommended to aliquot this antibody
- This antibody is not cross-reactive with other types of apoptotic inhibitor proteins at physiological conditions
- Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family
- The IAPs are involved in multiple cell functions such as cell signaling, cell division, metabolism, and exhibits differential expression in nearly all human cancers, but not in most normal tissues
- IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but the Survivin gene encodes proteins with only a single BIR domain
- The encoded proteins also lack a C-terminus RING finger domain
- Gene expression is high during fetal development and in most tumors yet low in adult tissues
- Antisense transcripts are involved in the regulation of survivin’s gene expression
- Survivin is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner
- At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics
- Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis
- Survivin may counteract a default induction of apoptosis in G2/M phase
- Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury
- Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein)
- Survivin might affect regulation of neural cell proliferative responses after brain injury
- At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined
- The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.