Tankyrase Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA517931-Each-of-1 | In Stock | ₹ 46,591.50 |
PIPA517931 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,591.50
GST (18%): ₹ 8,386.47
Total Price: ₹ 54,977.97
Antigen
Tankyrase
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TNKS
Gene Alias
4930554K12Rik; ADP-ribosyltransferase diphtheria toxin-like 5; AI662855; ARTD5; C86528; D130072O21Rik; HGNC:11941; LOW QUALITY PROTEIN: tankyrase-1; mTNKS1; PARP5A; PARP-5a; PARPL; pART5; Poly [ADP-ribose] polymerase 5A; Poly [ADP-ribose] polymerase tankyrase-1; poly [ADP-ribose] polymerase tankyrase-1; tankyrase-1; Protein poly-ADP-ribosyltransferase tankyrase-1; TANK1; tankyrase; tankyrase 1; tankyrase I; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; tankyrase-1; TIN1; TINF1; TNKS; TNKS1; TNKS-1; TRF1-interacting ankyrin-related ADP-ribose polymerase; TRF1-interacting ankyrin-related ADP-ribose polymerase 1
Host Species
Goat
Purification Method
Ammonium sulfate precipitation
Regulatory Status
RUO
Gene ID (Entrez)
8658
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.5 mg/mL
Formulation
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.
O95271
Gene Symbols
TNKS
Immunogen
Synthetic peptide sequence (RECOMBINANT) corresponding to the N-terminus amino acids of TNKS
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379)
- Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859)
- Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859)
- Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745)
- Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114)
- May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299)
- May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287)
- Stimulates 26S proteasome activity (PubMed:23622245)
- [UniProt]