alpha Dystroglycan Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA519323-Each-of-1 | In Stock | ₹ 46,858.50 |
PIPA519323 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,858.50
GST (18%): ₹ 8,434.53
Total Price: ₹ 55,293.03
Antigen
alpha Dystroglycan
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DAG1
Gene Alias
156DAG; A3a; AGRNR; Alpha-DG; Alpha-dystroglycan; Beta-DG; Beta-dystroglycan; D9Wsu13e; DAG; DAG1; Dag-1; DG; Dp427; Dp71; dystroglycan; dystroglycan 1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystrophin associated glycoprotein 1; Dystrophin-associated glycoprotein 1; MDDGA9; MDDGC7; MDDGC9
Host Species
Goat
Purification Method
Ammonium sulfate precipitation
Regulatory Status
RUO
Gene ID (Entrez)
1605
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.5 mg/mL
Formulation
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q14118
Gene Symbols
DAG1
Immunogen
Synthetic peptide sequence (HVGKHEYFMHATDK) corresponding to the internal amino acids of DAG1
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- This antibody is predicted to react with bovine and canine based on sequence homology
- This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000
- Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix
- Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies
- The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis
- Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane
- The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence
- Alternative splicing results in multiple transcript variants all encoding the same protein.