TDP-43 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA519712-Each-of-1 | In Stock | ₹ 51,486.50 |
PIPA519712 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 51,486.50
GST (18%): ₹ 9,267.57
Total Price: ₹ 60,754.07
Antigen
TDP-43
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TARDBP
Gene Alias
1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23435
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot, Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1% BSA and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q13148
Gene Symbols
TARDBP
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 350 to the C-terminus of Human TARDBP.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA5-19712 targets TARDBP in IF, IHC (F), IP, and WB applications and shows reactivity with Human and mouse samples
- The PA5-19712 immunogen is synthetic peptide conjugated to KLH derived from within residues 350 to the C-terminus of Human TARDBP
- PA5-19712 detects TARDBP which has a predicted molecular weight of approximately 47 kDa
- TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR
- Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"ee; splice site
- A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U)
- TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.