HTRA2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA520010-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA520010 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
HTRA2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HTRA2
Gene Alias
AI481710; High temperature requirement protein A2; HtrA serine peptidase 2; HtrA2; HtrA-like serine protease; mnd2; motor neuron degeneration 2; OMI; Omi stress-regulated endoprotease; PARK13; protease, serine, 25; Prss25; Serine protease 25; serine protease HTRA2, mitochondrial; serine protease OMI; serine proteinase OMI
Host Species
Rabbit
Purification Method
Ion-exchange chromatography
Regulatory Status
RUO
Gene ID (Entrez)
27429
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
O43464
Gene Symbols
HTRA2
Immunogen
A peptide corresponding to 16 amino acids near the C-terminus of human Omi.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A suggested positive control is U937 cell lysate
- PA5-20010 can be used with blocking peptide PEP-0130
- The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli
- All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3)
- Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli
- This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4)
- Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus
- The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.