IRGM Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA520508-Each-of-1 | In Stock | ₹ 49,706.50 |
PIPA520508 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,706.50
GST (18%): ₹ 8,947.17
Total Price: ₹ 58,653.67
Antigen
IRGM
Classification
Polyclonal
Conjugate
Unconjugated
Gene
IRGM
Gene Alias
Ifggd3; Ifi1; Iigp3; Iipg3; immunity related GTPase M; immunity related GTPase m1; immunity-related GTPase family M member 1; immunity-related GTPase family M protein; Immunity-related GTPase family M protein 1; immunity-related GTPase family, M; immunity-related GTPase family, M1; immunity-related GTPase M; interferon inducible protein 1; interferon-gamma-inducible GTPase Ifggd3 protein; interferon-inducible GTPase 3; Interferon-inducible protein 1; Irgm; Irgm1; LPS-stimulated RAW 264.7 macrophage protein 47; LPS-stimulated RAW 264.7 macrophage protein 47 homolog; LRG 47; LRG47; LRG-47; LRG-47-like protein; MGC149263
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
15944, 303090, 345611
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
A1A4Y4, Q60766, Q6AYC2
Gene Symbols
IRGM, Irgm1
Immunogen
A 14 amino acid peptide near the center of the human IRGM.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A suggested positive control is human brain tissue lysate
- PA5-20508 can be used with blocking peptide PEP-0628
- Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells
- It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components
- Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease
- In mouse, IRGM belongs to a family of -gamma-interferon-induced GTP-binding proteins of approximately 48 kDa
- Murine IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis
- Human IRGM is also involved in autophagy and plays a role in the control of intracellular pathogens and in the reduction of intracellular bacillary load.