IFIT3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA572807-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA572807 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
IFIT3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
IFIT3
Gene Alias
cig41; CIG49; CIG-49; Garg49; GARG-49; Glucocorticoid-attenuated response gene 49 protein; Ifi49; IFI60; IFI-60K; IFIT3; IFIT-3; IFIT4; IFIT-4; interferon induced protein with tetratricopeptide repeats 3; interferon-induced 60 kDa protein; Interferon-induced protein with tetratricopeptide repeats 3; interferon-induced protein with tetratricopeptide repeats 4; interferon-stimulated protein 60; IRG2; Isg49; ISG60; ISG-60; P49; P60; retinoic acid-induced gene G protein; RIG-G; RP11-149I23.4
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3437
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ELISA, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
O14879
Gene Symbols
IFIT3
Immunogen
IFIT3 antibody for an 18 amino acid peptide near the carboxy terminus of human IFIT3. The immunogen is within amino acids 380 - 430 of IFIT3.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication
- Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription
- Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27
- Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation
- IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels
- Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21
- Can negatively regulate the apoptotic effects of IFIT2.