CDCA8 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA520576-Each-of-1 | In Stock | ₹ 46,591.50 |
PIPA520576 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,591.50
GST (18%): ₹ 8,386.47
Total Price: ₹ 54,977.97
Antigen
CDCA8
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CDCA8
Gene Alias
4831429J16Rik; AU044747; BOR; Borealin; Cdca8; cell division cycle associated 8; cell division cycle-associated protein 8; D4Ertd421e; Dasra B; DasraB; dasra-B; embryonic stem cell-related; hDasra-B; MESrg; MESRGP; PESCRG3; Pluripotent embryonic stem cell-related gene 3 protein
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
500545, 52276, 55143
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q53HL2, Q6AXW0, Q8BHX3
Gene Symbols
CDCA8
Immunogen
A 19 amino acid peptide near the amino terminus of the human CDCA8.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A suggested positive control is rat kidney tissue lysate
- PA5-20576 can be used with blocking peptide PEP-0696
- CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle
- The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division
- It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase
- CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues
- In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation
- Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53
- Its aberrant expression is linked to a poor prognosis for gastric cancer.