CDK4 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA580461-Each-of-1 | In Stock | ₹ 32,307.00 |
PIPA580461 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,307.00
GST (18%): ₹ 5,815.26
Total Price: ₹ 38,122.26
Antigen
CDK4
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Cdk4
Gene Alias
Cdk4; Cell division protein kinase 4; CMM3; Crk3; cyclin dependent kinase 4; cyclin-dependent kinase 4; MGC14458; p34<PSK-J3>/cdk4; PSK-J3; serine/threonine kinase; Unknown (protein for MGC:133903)
Host Species
Rabbit
Purification Method
Antigen affinity chromatography, Protein A
Regulatory Status
RUO
Gene ID (Entrez)
1019
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
P11802
Gene Symbols
Cdk4
Immunogen
A synthetic peptide corresponding to the N-terminus of the Human CDK4
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
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Description
- This product is preservative free
- It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
- This antibody has specificity for Human CDK4
- CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex
- CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle
- CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2)
- CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex
- CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins
- SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2
- Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.