TREX1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA520665-Each-of-1 | In Stock | ₹ 49,083.50 |
PIPA520665 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,083.50
GST (18%): ₹ 8,835.03
Total Price: ₹ 57,918.53
Antigen
TREX1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TREX1
Gene Alias
1661; 3' repair exonuclease 1; 3'-5' exonuclease TREX1; AGS1; AU041952; CRV; Deoxyribonuclease III; DNase III; DRN3; HERNS; RGD1309596; three prime exonuclease 1; three prime repair exonuclease 1; three-prime repair exonuclease 1; Trex1; trophoblast expressed 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
100049583, 11277, 22040
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q91XB0, Q9NSU2
Gene Symbols
TREX1
Immunogen
A 15 amino acid peptide near the center of human TREX1.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A suggested positive control is human spleen tissue lysate
- PA5-20665 can be used with blocking peptide PEP-0785
- Trex1 (ATRIP) is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage
- It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress
- Trex1 is required for ATR expression
- This gene uses two different open reading frames
- The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint
- The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III
- Multiple transcript variants encoding different isoforms have been found
- Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.