SPG11 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA520683-Each-of-1 | In Stock | ₹ 46,591.50 |
PIPA520683 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,591.50
GST (18%): ₹ 8,386.47
Total Price: ₹ 54,977.97
Antigen
SPG11
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SPG11
Gene Alias
6030465E24Rik; A330015I11; ALS5; C530005A01Rik; CMT2X; Colorectal carcinoma-associated protein; KIAA1840; RGD1562529; spastic paraplegia 11; spastic paraplegia 11 (autosomal recessive); spastic paraplegia 11 protein; Spastic paraplegia 11 protein homolog; spatacsin; Spg11
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
214585, 311372, 80208
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q3UHA3, Q96JI7
Gene Symbols
SPG11
Immunogen
A 15 amino acid synthetic peptide near the carboxy terminus of human SPG11
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A suggested positive control is mouse heart tissue lysate
- PA5-20683 can be used with blocking peptide PEP-0799
- Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders
- Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia (cHSP) in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration
- Mutations of the SPG11 gene encoding the spatacsin protein have been identified as a major cause of HSP-TCC
- Spatacsin is a potential transmembrane protein that is phosphorylated upon DNA damage
- It is expressed in all structures of the brain, with a high expression in the cerebellum
- SPG11 mutations may occur more frequently in familial than sporadic forms of cHSP without TCC
- Kjellin syndrome is found to be associated with mutations in not only the SPG15 gene but also SPG11 gene
- Recent studies show Parkinsonism may initiate SPG11-linked HSP TCC and that SPG11 may cause juvenile Parkinsonism.