ABCB11 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA527742-Each-of-1 | In Stock | ₹ 49,439.50 |
PIPA527742 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,439.50
GST (18%): ₹ 8,899.11
Total Price: ₹ 58,338.61
Antigen
ABCB11
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ABCB11
Gene Alias
ABC member 16, MDR/TAP subfamily; ABC16; Abcb11; ATP binding cassette subfamily B member 11; ATP-binding cassette sub-family B member 11; ATP-binding cassette, subfamily B (MDR/TAP), member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; ATP-binding cassette, sub-family B, member 11; bile salt export pump; BRIC2; Bsep; Lith1; PFIC2; PFIC-2; PGY4; progressive familial intrahepatic cholestasis 2; sister of P-glycoprotein; sister p-glycoprotein; Spgp
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
8647
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1.17 mg/mL
Formulation
1 XPBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
O95342
Gene Symbols
ABCB11
Immunogen
Recombinant fragment corresponding to a region within amino acids 474 and 745 of Human BSEP
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: Jurkat
- Predicted reactivity: Mouse (85%), Rat (87%), Dog (84%), Cat (87%), Rabbit (85%), Bovine (88%), Guinea pig (81%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes
- It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes
- Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain
- Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2)
- PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity
- Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.