Syk Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA528574-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA528574 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Syk
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Syk
Gene Alias
DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; SYK; syk signaling; Sykb; tyrosine-kinase syk; tyrosine-protein kinase SYK
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
20963, 25155, 6850
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1.02 mg/mL
Formulation
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
P43405, P48025, Q64725
Gene Symbols
Syk
Immunogen
Recombinant protein fragment corresponding to a region within amino acids 1 and 283 of Human SYK
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: A431, Raji
- Predicted reactivity: Mouse (89%), Rat (89%), Pig (90%), Chicken (81%), Rhesus Monkey (91%), Bovine (89%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases
- SYK may also play a role in cancer
- Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes
- Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases
- These kinases also help to activate Syk by phosphorylation of its activation loop.