SPHK1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA528584-Each-of-1 | In Stock | ₹ 46,591.50 |
PIPA528584 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,591.50
GST (18%): ₹ 8,386.47
Total Price: ₹ 54,977.97
Antigen
SPHK1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SPHK1
Gene Alias
1110006G24Rik; Acetyltransferase SPHK1; RP23-193A16.4; SK 1; Sk1; SKase; Sphingosine kinase 1; SPHK; SPHK1; SPK; SPK 1; Spk1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
8877
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
Q9NYA1
Gene Symbols
SPHK1
Immunogen
Recombinant protein fragment corresponding to a region within amino acids 1 and 220 of Human SPHK1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji
- Predicted reactivity: Human (99%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P)
- S1P signals through G-protein coupled receptors and controls diverse cellular processes
- Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer
- SPHK1 catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions
- Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine
- S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis
- The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).