Complement C9 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA529066-Each-of-1 | In Stock | ₹ 46,591.50 |
PIPA529066 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,591.50
GST (18%): ₹ 8,386.47
Total Price: ₹ 54,977.97
Antigen
Complement C9
Classification
Polyclonal
Conjugate
Unconjugated
Gene
C9
Gene Alias
ARMD15; C9; C9D; complement C9; complement component 9; complement component C9; Complement component C9a; Complement component C9b; complement protein C9; complement protein C9 precursor
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
735
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
P02748
Gene Symbols
C9
Immunogen
Recombinant fragment corresponding to a region within amino acids 153 and 429 of Human C9
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: Jurkat
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum
- Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 complex
- The last step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane
- During formation of C5b-8 and C9 polymerization, neoantigens are generated which are unique to the C5b-9 complex and are not present on any of the individual native complex components
- The complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane
- The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive
- C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage
- Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex forming is abrogated.