ARC Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA529389-Each-of-1 | In Stock | ₹ 46,057.50 |
PIPA529389 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,057.50
GST (18%): ₹ 8,290.35
Total Price: ₹ 54,347.85
Antigen
ARC
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NOL3
Gene Alias
activity regulated cytoskeletal-associated protein; activity regulated cytoskeleton associated protein; activity-regulated cytoskeleton-associated protein; Activity-regulated gene 3.1 protein; activity-regulated gene 3.1 protein homolog; Apoptosis repressor with CARD; ARC; arc {ECO:0000312; ARC/ARG3.1; Arc3.1; Arg3.1; B430311C09Rik; C86064; FCM; hArc; KIAA0278; mArc; Muscle-enriched cytoplasmic protein; MYC; MYP; Nol3; NOP; Nop 30; Nop30; Nucleolar protein 3; nucleolar protein 3 (apoptosis repressor with CARD domain); nucleolar protein of 30 kDa; rg3.1; RGD:62037}
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
8996
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.64 mg/mL
Formulation
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
O60936
Gene Symbols
NOL3
Immunogen
Synthetic peptide corresponding to a region within amino acids 138 and 192 of Human NOL3
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Raji
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms
- Isoform 1 is involved in RNA splicing
- Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death
- ARC inhibits extrinsic apoptotic pathways two different ways
- The first is by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly
- The second way is by interacting with CASP8 in a mitochondria localization-and phosphorylation-dependent manner, which in turn limits the amount of soluble CASP8 avaliable for DISC-mediated activation
- ARC also inhibits intrinsic apoptotic pathways in response to a wide range of stresses through interactions with BAX
- This results in BAX inactivation and prevents mitochondrial dysfunction and release of pro-apoptotic factors
- Mutations affecting the gene can results in myoclonus, familiam cortical.