TrxR2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA529458-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA529458 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
TrxR2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TXNRD2
Gene Alias
AA118373; ESTM573010; KIAA1652; Selenoprotein Z; SelZ; TGR; thioredoxin reductase 2; thioredoxin reductase 2, mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; thioredoxin reductase TR3; TR; TR beta; TR3; TR-BETA; Trxr2; Trxrd2; TXNRD2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10587
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
Q9NNW7
Gene Symbols
TXNRD2
Immunogen
Recombinant protein fragment corresponding to a region within amino acids 207 and 524 of Human TrxR2
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: HepG2
- Predicted reactivity: Mouse (80%), Rat (80%), Rhesus Monkey (97%), Guinea pig (86%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide-disulfide oxidoreductases
- All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) but distinctively with a C-terminal extension containing a catalytically active penultimate selenocysteine (SeCys) residue in the conserved sequence (-Gly-Cys-SeCys-Gly)
- TrxR is homodimeric protein in which each monomer includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site
- Electrons are transferred from NADPH via FAD and the active-site disulfide to C-terminal SeCys-containing redox center, which then reduces the substrate like thioredoxin
- The members of TrxR family are 55-58 kilodalton in molecular size and composed of three isoforms including cytosolic TrxR1, mitochondrial TrxR2, and TrxR3, known as Trx and GSSG reductase (TGR)
- TrxR plays a key role in protection of cells against oxidative stress and redox-regulatory mechanism of transcription factors and various biological phenomena.