ERO1L Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA529535-Each-of-1 | In Stock | ₹ 45,968.50 |
PIPA529535 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,968.50
GST (18%): ₹ 8,274.33
Total Price: ₹ 54,242.83
Antigen
ERO1L
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ERO1A
Gene Alias
Endoplasmic oxidoreductin-1-like protein; endoplasmic reticulum oxidation 1; endoplasmic reticulum oxidoreductase 1 alpha; endoplasmic reticulum oxidoreductase alpha; Endoplasmic reticulum oxidoreductin-1-like protein; ero1; ERO1A; Ero1alpha; ERO1-alpha; ERO1L; ERO1-L; ERO1LA; ERO1-L-alpha; ERO1-like; ERO1-like (S. cerevisiae); ERO1-like protein alpha; Giig11; Global ischemia-induced protein 11; oxidoreductin-1-L-alpha; UNQ434/PRO865
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
30001, 423585, 50527
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.95 mg/mL
Formulation
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
Q96HE7
Gene Symbols
ERO1A
Immunogen
Recombinant fragment corresponding to a region within amino acids 99 and 410 of Human ERO1L
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Chicken, Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: HCT116, MCF-7, mouse stomach
- Predicted reactivity: Rat (90%), Pig (96%), Rhesus Monkey (99%), Bovine (96%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- ERO1L (endoplasmic oxidoreductin-1-like protein) is localized in ER membrane as peripheral membrane protein on the lumenal side
- Its association with ERP44 is essential for its retention in the ER and is unique in coupling oxygen reduction to de novo disulfides formation
- The ERO1L enzyme is broadly distributed at low levels in several tissues with highest levels in the upper digestive tract and is stimulated by hypoxia via HIF-signaling
- ERO1L generally exists as monomer, but has the ability to function as monomer or homodimer and interacts with PDILT
- After translation, ERO1L gets n-glycosylated and the disulfide bonds constitute the redox-active center whereby the Cys-94/Cys-99 disulfide bond accepts an electron from P4HB followed by funneling the same to the active site disulfide Cys-394/Cys-397
- ERO1L acts by oxidizing directly to P4HB/PDI isomerase through direct disulfide exchange and associates with ERP44
- ERO1L is implicated in immunoglobulin folding, oxidative stress, release of unfolded cholera toxin from reduced P4HB/PDI upon Vibrio cholerae infection, and plays a key role in ER stress-induced CHOP-dependent apoptosis through inositol 1,4,5-trisphosphate receptor IP3R1 activation.