Cyclophilin A Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA529752-Each-of-1 | In Stock | ₹ 47,570.50 |
PIPA529752 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,570.50
GST (18%): ₹ 8,562.69
Total Price: ₹ 56,133.19
Antigen
Cyclophilin A
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Ppia
Gene Alias
2700098C05; Cphn; CYCA; cyclophilin; Cyclophilin A; Cyclosporin A-binding protein; CyP A; CyP-18; CYPA; CyP-A; CYPH; EC 5.2.1.8; epididymis secretory sperm binding protein Li 69p; HEL-S-69p; HGNC:9253; I79_011869; MGC117158; MGC12404; MGC23397; p1B15; p31; Peptidyl-prolyl cis-trans isomerase A; Peptidyl-prolyl cis-trans isomerase A, N-terminally processed; peptidylprolyl isomerase A; peptidylprolyl isomerase A (cyclophilin A); PPIA; PPIase; PPIase A; rotamase; rotamase A; SP18; T cell cyclophilin
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
25518, 268373, 5478
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
P10111, P17742, P62937
Gene Symbols
Ppia
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 165 of Human Cyclophilin A
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: Raji WCE, Raji C+M, Raji NE, Molt-4, Raji, Mouse brain
- Predicted reactivity: Mouse (96%), Rat (96%), Cat (98%), Pig (99%), Rabbit (96%), Chicken (92%), Sheep (99%), Rhesus Monkey (100%), Bovine (94%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506
- Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP)
- Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506
- Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds
- As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins
- Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC
- CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.