Cortactin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA529799-Each-of-1 | In Stock | ₹ 51,575.50 |
PIPA529799 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 51,575.50
GST (18%): ₹ 9,283.59
Total Price: ₹ 60,859.09
Antigen
Cortactin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Cttn
Gene Alias
1110020L01Rik; amplaxin; cortactin; Cttn; Cttnb; EMS1; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate); FLJ34459; mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); oncogene EMS1; Oncogene SRC8; Src substrate cortactin; src8; Unknown (protein for MGC:137923)
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
13043, 2017, 60465
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.28 mg/mL
Formulation
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
Q14247, Q60598, Q66HL2
Gene Symbols
Cttn
Immunogen
Recombinant protein fragment corresponding to a region within amino acids 1 and 276 of Human Cortactin
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: HeLa, Neuro 2A, C8D30, NIH-3T3, C2C12, PC-12, Rat2, mouse brain, rat brain
- Predicted reactivity: Mouse (98%), Rat (99%), Chicken (93%), Rhesus Monkey (100%), Bovine (85%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- Cortactin (Cttn) is a ubiquitous actin-binding protein that was originally identified as a substrate for Src
- It contributes to the organization of the actin cytoskeleton and cell shape
- Cortactin also plays a role in the formation of lamellipodia and cell migration
- It is accumulated in peripheral, actin-enriched structures of cells suggesting that cortactin facilitates actin network formation
- Cortactin has four major domains of interest the N-terminal acidic (NTA) and tandem repeats domains and the C-terminal proline-rich and SH3 Domains
- NTA associates with the Arp2/3 and WASP complex at F-actin branches
- Cortactin is involved in promoting cell motility and invasion, including a critical role in invadopodia, actin rich-subcellular protrusions associated with degradation of the ECM by cancer cells
- Cortactin is phosphorylated by src family kinases at Y421, Y466, and Y482 and S405 and S418 that are phosphorylated by Erk family kinases.