TDP-43 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA529949-Each-of-1 | In Stock | ₹ 52,866.00 |
PIPA529949 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,866.00
GST (18%): ₹ 9,515.88
Total Price: ₹ 62,381.88
Antigen
TDP-43
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TARDBP
Gene Alias
1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
230908, 23435, 298648
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ChIP sequencing (ChIP-seq), Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
0.63 mg/mL
Formulation
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
Q13148, Q921F2
Gene Symbols
TARDBP
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 289 of Human TARDBP
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: 293T, A431, HeLa, HepG2, Neuro2A, GL261, NIH-3T3, BCL-1, Raw264.7, PC-12, Rat-2, Rat brain
- Predicted reactivity: Mouse (95%), Rat (95%), Zebrafish (83%), Xenopus laevis (91%), Chicken (95%), Bovine (96%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR
- Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"ee; splice site
- A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U)
- TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.