SATB1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA530163-Each-of-1 | In Stock | ₹ 52,154.00 |
PIPA530163 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,154.00
GST (18%): ₹ 9,387.72
Total Price: ₹ 61,541.72
Antigen
SATB1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Satb1
Gene Alias
2610306G12Rik; AW413156; DNA-binding protein SATB1; SATB homeobox 1; Satb1; special AT-rich sequence binding protein 1; special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA); special AT-rich sequence-binding protein 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
20230, 6304
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ChIP Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
0.36 mg/mL
Formulation
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
Q01826, Q60611
Gene Symbols
Satb1
Immunogen
Recombinant fragment corresponding to a region within amino acids 514 and 749 of Human SATB1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: Jurkat, THP-1, mouse thymus
- Predicted reactivity: Mouse (96%), Rat (96%), Chicken (91%), Rhesus Monkey (99%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- SATB1 (DNA-binding protein SATB1) is a crucial silencing factor that contributes to the initiation of X inactiviation mediated by Xist RNA that occurs during embryogenesis and in lymphoma
- SATB1 binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence, and at nuclear matrix- or scaffold-associated regions
- It is thought to recognize the sugar-phosphate structure of double-stranded DNA
- SATB1 is also a transcriptonal repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner by binding to matrix attachment regions of DNA and inducing a local chromatin-loop remodeling
- SATB1 modulates the genes that are essential in the maturatio of the immune T-cell CD8SP from thymocytes
- Alu-like motifs and SATB1-binding sites provide an unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery
- Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL1 and IL2RA in T-cells by binding to the same domain as HDAC1.