GNB1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA530046-Each-of-1 | In Stock | ₹ 49,439.50 |
PIPA530046 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,439.50
GST (18%): ₹ 8,899.11
Total Price: ₹ 58,338.61
Antigen
GNB1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
GNB1
Gene Alias
AA409223; beta subunit, signal-transducing proteins GS/GI; C77571; G protein subunit beta 1; gbb1; GNB1; Gnb-1; gnb1 protein; gnb1a; guanine nucleotide binding protein (G protein), beta 1; guanine nucleotide binding protein (G protein), beta polypeptide 1; guanine nucleotide binding protein (G protein), beta polypeptide 1a; guanine nucleotide binding protein, beta 1; Guanine nucleotide-binding protein beta 1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; guanine nucleotide-binding protein, beta-1 subunit; MRD42; T beta; testicular tissue protein Li 72; transducin beta chain 1; transducin beta subunit; unnamed protein product; wu:fb50b09; wu:fj94h04
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
14688, 24400, 2782
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
1.44 mg/mL
Formulation
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
P54311, P62873, P62874
Gene Symbols
GNB1
Immunogen
Recombinant protein fragment corresponding to a region within amino acids 67 and 271 of Human GNB1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: Jurkat, Raji, NCI-H929, Mouse brain
- Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (96%), Dog (100%), Chicken (97%), Rhesus Monkey (100%), Bovine (100%), Guinea pig (100%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to and interpreted by the brain
- The process of converting light into an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina
- Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active
- In the active state, rhodopsin activates transducin, a GTP binding protein
- Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE)
- The decrease of intracellular cGMP concentration causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission
- Rhodopsin activity is believed to be shut off by phosphorylation followed by binding of the soluble protein, arrestin
- Transducin, once activated by rhodopsin, promotes the hydrolysis of cGMP by PDE
- The subunit composition of transducin differs between different photoreceptor cells
- Rod transducin consists of rod transducin alpha (Tr alpha), T beta, and T gamma
- Cone transducin is composed of cone transducin alpha (Tc alpha), T beta and T gamma
- Differential transducin subunit composition of transducin is believed to be responsible for the different light sensitivities between photoreceptive cells.