ITGB1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA529606-Each-of-1 | In Stock | ₹ 52,599.00 |
PIPA529606 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,599.00
GST (18%): ₹ 9,467.82
Total Price: ₹ 62,066.82
Antigen
ITGB1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ITGB1
Gene Alias
4633401G24Rik; AA409975; AA960159; Beta OL; beta oligodendroglia; CD29; CSAT antigen; ENSMUSG00000051907; Fibronectin receptor subunit beta; FNRB; Glycoprotein IIa; Gm9863; gpIIa; integrin beta 1; integrin beta 1 (fibronectin receptor beta); integrin beta 1A precursor; Integrin beta1; integrin beta-1; integrin beta-1 subunit; integrin beta1D; integrin precursor; integrin subunit beta 1; integrin VLA-4 beta subunit; integrin VLA-4 subunit beta; integrin, beta 1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITBG1D; ITGB1; JG22 antigen; MDF2; MSK12; RGD-receptor; very late activation protein, beta polypeptide; VLA-4 subunit beta; VLAB; VLA-BETA
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3688
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
P05556
Gene Symbols
ITGB1
Immunogen
Recombinant fragment corresponding to a region within amino acids 128 and 410 of Human Integrin beta 1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: U87-MG, SK-N-SH, IMR32, SK-N-AS, human ITGB1-transfected 293T
- Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (91%), Cat (98%), Pig (98%), Chicken (94%), Sheep (98%), Bovine (97%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein that is widely expressed by a variety of cells including all leucocytes
- ITGB1 forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CDa-f) determining the binding properties of beta1 (VLA) integrins
- ITGB1 is a cell adhesion molecule appearing on platelets, as the common Beta subunit of the very late activation antigen (VLA), and as a component of various protein complexes binding to extracellular matrix proteins
- Decreased expression of ITGB1 correlates with acquiring multidrug resistance of tumor cells in the presence of anti-tumor drug
- ITGB1 is up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue
- Further, ITGB1 also regulates tissue damage and disease symptoms related to inflammatory bowel disease
- Through an ITGB1-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta
- More than 8 beta subunits with numerous splice variant isoforms have been identified in mammals
- There are two major forms of integrin beta1: beta1A and beta1D, which differ in 13 amino acids
- The distribution pattern in adult tissues for integrin beta types are mutually exclusive
- Beta1A is present in all tissues, except cardiac and skeletal muscle which express the beta1D variant.