PIPA533575
GALR2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA533575-Each-of-1 | In Stock | ₹ 46,591.50 |
PIPA533575 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,591.50
GST (18%): ₹ 8,386.47
Total Price: ₹ 54,977.97
Antigen
GALR2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Galr2
Gene Alias
Gal receptor 2; Gal-2 receptor; GAL2-R; Galanin r2 receptor; galanin receptor 2; galanin receptor type 2; Galanin-2 receptor; Galnr2; GALR2; Gal-r2; GALR-2; mGalR; MGC125983; MGC125984
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
8811
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry (Paraffin)
Concentration
1 mg/mL
Formulation
PBS with 0.1% sodium azide
Gene Accession No.
O43603
Gene Symbols
Galr2
Immunogen
Synthetic 18 amino acid peptide from 7th transmembrane domain of human GALR2.
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Percent identity with other species by BLAST analysis: Human (100%) Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Bovine, Horse (94%) Panda, Dog, Bat (89%)
- GalR2 expression has been documented widely in the brain and in peripheral tissues including small intestine, heart, kidney, and liver
- Localization data from rat CNS indicate high levels of expression in dorsal root ganglia, amygdala, and Purkinje neurons
- G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist
- All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms
- An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors
- Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs
- This "eturn-off"e activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates
- Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.