C14orf126 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA551516-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA551516 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
C14orf126
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DTD2
Gene Alias
4930578F06Rik; 6530401N04Rik; Animalia-specific tRNA deacylase; ATD; B830049N13Rik; C14orf126; D-aminoacyl-tRNA deacylase 2; DTD2; D-tyrosyl-tRNA deacylase 2; D-tyrosyl-tRNA deacylase 2 (putative); D-tyrosyl-tRNA(Tyr) deacylase 2; L-alanyl-tRNA deacylase; probable D-tyrosyl-tRNA(Tyr) deacylase 2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
112487
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry
Concentration
0.1 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q96FN9
Gene Symbols
DTD2
Immunogen
Recombinant protein corresponding to Human C14orf126
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: WVEVQRGLVI YVCFFKGADK ELLPKMVNTL LNVKLSETEN GKHVSILDLP GNILIIPQAT LGGRLKGRNM QYHSNSGKEE GFELYSQFVT LCEKEVAANS KCAEARVVVE HGTYGNRQVL KLDTNGPFTH LIFE Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 85%
- Deacylates mischarged D-aminoacyl-tRNAs
- Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS
- Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids
- Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr)
- By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
- In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408)
- Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408)
- Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation
- [UniProt]