LAMTOR1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA551792-Each-of-1 | In Stock | ₹ 52,421.00 |
PIPA551792 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,421.00
GST (18%): ₹ 9,435.78
Total Price: ₹ 61,856.78
Antigen
LAMTOR1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
LAMTOR1
Gene Alias
2400001E08Rik; C11orf59; Lamtor1; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1; lipid raft adaptor protein p18; p18; p27kip1 releasing factor from RhoA; p27Kip1-releasing factor from RhoA; p27RF Rho; p27RF-Rho; Pdro; PP7157; Protein associated with DRMs and endosomes; ragulator complex protein LAMTOR1; ragulator complex protein PDRO; Ragulator1; RhoA activator C11orf59; RhoA activator C11orf59 homolog
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
55004
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry
Concentration
0.2 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q6IAA8
Gene Symbols
LAMTOR1
Immunogen
Recombinant protein corresponding to Human LAMTOR1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: NEDSDQDREE RKLLLDPSSP PTKALNGAEP NYHSLPSART DEQALLSSIL AKTASNIIDV SAADSQGMEQ HEYMDRARQY STRLAVLSSS LTHWKKLPPL PSLTSQPHQV LASEPIPFSD LQQVSRIAAY AYSALSQIRV DAKEELVV Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 97%
- The Ragulator complex is comprised of three proteins, C11orf59, ROBLD3, and MAPKSP1, which targets mTORC1 to lysosomal surfaces
- This normal endosomal trafficking is taken advantage of by certain viruses, including coronavirus, which has increased replication when C11orf59 is interfered with
- C11orf59 is positively regulated by cellular cholesterol depletion and negatively regulated by cellular cholesterol loading
- It is involved in LDL uptake and cholesterol homeostasis
- C11orf59 and PPAR-alpha work together to control lipid and carbohydrate metabolism in diabetes
- Nearly all effects of C11orf59 are associated with mTORC1 kinase growth promotion, and disregulation of the normal mTOR pathway.