PHLDA1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA553889-Each-of-1 | In Stock | ₹ 52,866.00 |
PIPA553889 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,866.00
GST (18%): ₹ 9,515.88
Total Price: ₹ 62,381.88
Antigen
PHLDA1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PHLDA1
Gene Alias
apoptosis-associated nuclear protein; DT1P1B11; PHLDA1; PHRIP; pleckstrin homology like domain family A member 1; pleckstrin homology-like domain family A member 1; pleckstrin homology-like domain, family A, member 1; PQR protein; PQ-rich protein; proline- and glutamine-rich protein; Proline- and histidine-rich protein; proline-histidine rich protein; T-cell death associated; T-cell death-associated gene 51 protein; Tdag; TDAG51
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
22822
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
0.1 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q8WV24
Gene Symbols
PHLDA1
Immunogen
Recombinant protein corresponding to Human PHLDA1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: RMLESSGCKA LKEGVLEKRS DGLLQLWKKK CCILTEEGLL LIPPKQLQHQ QQQQQQQQQQ QQQPGQGPAE PSQPSGPAVA SLEPPVKLKE LHFSNMKTVD CVE Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 91%
- Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immunosurveillance against virus-infected or -transformed cells
- Two mechanisms appear to account for this activity, one of which is the perforin-based process
- Independently, a FAS-based mechanism involves the transducing molecule FAS (APO-1) and its ligand (FAS-L)
- The human FAS (APO-1) protein is a 48 kDa cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors
- The FAS antigen is expressed on a broad range of lymphoid cell lines, and is expressed at high levels in T cells subsequent to crosslinking of the T cell receptor (TCR)
- A previously undescribed protein, TDAG51, restores activation- induced apoptosis in cells that have lost the ability to display Fas in response to activation.