SCO1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA554452-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA554452 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
SCO1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SCO1
Gene Alias
2610001C07Rik; D11Bwg1310e; Protein SCO1 homolog, mitochondrial; RGD1559538; SCO cytochrome c oxidase assembly protein 1; SCO cytochrome oxidase deficient homolog 1; SCO cytochrome oxidase deficient homolog 1 (yeast); SCO1; SCO1 cytochrome c oxidase assembly protein; SCO1, cytochrome c oxidase assembly protein; SCOD1; synthesis of cytochrome C oxidase 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6341
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
0.4 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
O75880
Gene Symbols
SCO1
Immunogen
Recombinant protein corresponding to Human SCO1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: TREEVDQVAR AYRVYYSPGP KDEDEDYIVD HTIIMYLIGP DGEFLDYFGQ NKRKGEIAAS IATHMRPYR Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 86%
- Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane
- Like their yeast homologs, the function of both SCO1 and SCO2 are dependent on copper ion binding
- Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional, suggesting the pathology is due to loss of function
- It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion, thus impairing the efficiency of copper transfer to the cytochrome c oxidase.