HOXA11 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA557341-Each-of-1 | In Stock | ₹ 52,332.00 |
PIPA557341 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,332.00
GST (18%): ₹ 9,419.76
Total Price: ₹ 61,751.76
Antigen
HOXA11
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HOXA11
Gene Alias
homeo box 1I; homeo box A11; homeobox A11; homeobox protein Hox-1.9; Homeobox protein Hox-1I; homeobox protein HOXA11; homeobox protein Hox-A11; HOX1; Hox-1.9; HOX11; HOX1I; Hoxa11; Hoxa-11; NEWGENE_1564605; RUSAT1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3207
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
P31270
Gene Symbols
HOXA11
Immunogen
Recombinant protein corresponding to Human HOXA11
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: EVTFREYAIE PATKWHPRGN LAHCYSAEEL VHRDCLQAPS AAGVPGDVLA KSSANVYHHP TPAVSSNFY Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%
- HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region
- It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus
- HOX11 is required for maintenance of the developing spleen and cell survival
- The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus
- It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator
- The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t (10:14) (q24;qll) translocation
- The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes
- HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.