NPRL2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA558289-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA558289 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
NPRL2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NPRL2
Gene Alias
2810446G01Rik; G21; G21 protein; GATOR complex protein NPRL2; Gene 21 protein; homologous to yeast nitrogen permease (candidate tumor suppressor); nitrogen permase homolog; nitrogen permease regulator 2-like protein; nitrogen permease regulator-like 2; nitrogen permease regulator-like 2 (S. cerevisiae); NPR 2L; NPR L2; NPR like 2; NPR2; NPR2 like; NPR2L; NPR2-like protein; NPR2-like, GATOR1 complex subunit; NPRL 2; Nprl2; Tumor suppressor candidate 4; TUSC 4; TUSC 4 protein; TUSC4; TUSC4 protein
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10641
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry
Concentration
0.05 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q8WTW4
Gene Symbols
NPRL2
Immunogen
Recombinant protein corresponding to Human NPRL2
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: KLIQFGLMKN LIRRLQKYPV RVTREEQSHP ARLYTGCHSY DEICCKTGMS YHELDERLEN DPNIIICW Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%
- NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein that contains a bipartite nuclear localization signal and a granulin protein-binding domain
- It is highly expressed in skeletal muscle, followed by brain, liver and pancreas, with lower expression in lung, kidney, placenta and heart
- NPRL2 is also expressed in most lung cancer cell lines and may be involved in tumor suppression
- NPRL2 may play a role in mismatch repair, cell cycle checkpoint signaling and activation of apoptotic pathways
- It may also enhance the therapeutic efficacy of chemotherapy drugs such as cis-platin by resensitizing patients resistant to cisplatin treatment
- The gene encoding NPRL2 is conserved between species and is expressed as two isoforms due to alternative splicing events.