YTHDF2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA565839-Each-of-1 | In Stock | ₹ 49,439.50 |
PIPA565839 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,439.50
GST (18%): ₹ 8,899.11
Total Price: ₹ 58,338.61
Antigen
YTHDF2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
YTHDF2
Gene Alias
9430020E02Rik; CAHL; CLL-associated antigen KW-14; HGRG8; high glucose-regulated protein 8; high-glucose-regulated protein 8; LOW QUALITY PROTEIN: YTH domain-containing family protein 2; NY-REN-2; renal carcinoma antigen NY-REN-2; YTH domain family 2; YTH domain family protein 2; YTH domain family, member 2; YTH domain-containing family protein 2; YTH N(6)-methyladenosine RNA binding protein 2; YTH N6-methyladenosine RNA binding protein 2; yth2; YTHDF2; zgc:56224
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
51441
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry
Concentration
0.10 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q9Y5A9
Gene Symbols
YTHDF2
Immunogen
Recombinant Human YTHDF2
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: RNRGSGFGHNG VDGNGVGQSQ AGSGSTPSEP HPVLEKLRSI NNY Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%
- Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability
- M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability
- Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation
- Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation.