YTHDF1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA589122-Each-of-1 | In Stock | ₹ 45,968.50 |
PIPA589122 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,968.50
GST (18%): ₹ 8,274.33
Total Price: ₹ 54,242.83
Antigen
YTHDF1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
YTHDF1
Gene Alias
2210410K23Rik, 8030473O16, C20orf21, DACA-1, DACA-1 homolog, Dermatomyositis associated with cancer putative autoantigen 1, dermatomyositis associated with cancer putative autoantigen 1 homolog, fb49c02, wu:fb49c02, wu:fi19h06, wu:fj87f09, wu:fp06c11, YTH domain family 1, YTH domain family protein 1, YTH domain family, member 1, YTH domain-containing family protein 1, YTH N(6)-methyladenosine RNA binding protein 1, YTH N6-methyladenosine RNA binding protein 1, Ythdf1, zgc:55657
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
228994, 296467, 54915
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Concentration
0.92 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
P59326, Q9BYJ9
Gene Symbols
YTHDF1
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human YTHDF1 (NP_0602682)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: HepG2, Jurkat; Cellular Location: Cytoplasm Immunogen sequence: MSATSVDTQR TKGQDNKVQN GSLHQKDTVH DNDFEPYLTG QSNQSNSYPS MSDPYLSSYY PPSIGFPYSL NEAPWSTAGD PPIPYLTTYG QLSNGDHHFM HDAVFGQPGG LGNNIYQHRF NFFPENPAFS AWGTSGSQGQ QTQSSAYGSS YTYPPSSLGG TVVDGQPGFH SDTLSKAPGM NSLEQGMVGL KIGDVSSSAV Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451)
- M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625)
- Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440)
- Required to facilitate learning and memory formation in the hippocampus by enhancing protein synthesis upon neuronal stimulation: in response to neuronal stimulation, binds to m6A-containing neuronal mRNAs, promoting their translation, thereby contributing to learning and memory
- Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts, thereby promoting their translation
- Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells
- Acts by binding and promoting translation of m6A-containing transcripts encoding proteins involved in lysosomal degradation and phagosome maturation, leading to increased antigen degradation in myeloid dendritic cells
- In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation
- [UniProt]