UNC5A Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA567592-Each-of-1 | In Stock | ₹ 46,057.50 |
PIPA567592 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,057.50
GST (18%): ₹ 8,290.35
Total Price: ₹ 54,347.85
Antigen
UNC5A
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Unc5a
Gene Alias
Kiaa1976; mKIAA1976; netrin receptor UNC5A; netrin receptor Unc5h1; protein unc-5 homolog 1; Protein unc-5 homolog A; transmembrane receptor Unc5H1; unc5 (C.elegans homolog) a; unc5 homolog 1; unc-5 homolog 1; unc-5 homolog A; unc-5 homolog A (C. elegans); unc-5 netrin receptor A; UNC5A; Unc5h1; UNC5H1FLJ16449
Host Species
Rabbit
Purification Method
affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
107448, 60629, 90249
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.7 mg/mL
Formulation
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
O08721, Q6ZN44, Q8K1S4
Gene Symbols
Unc5a
Immunogen
Synthesized peptide derived from human UNC5A.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Predicted to react with Mouse and Rat samples
- The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells
- Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain, UNC5H receptors induce apoptosis
- This activity is blocked by the binding of netrin-1
- In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity
- The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers
- UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane
- Three isoforms of UNC5H1 exist due to alternative splicing events.