ULK1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA577810-Each-of-1 | In Stock | ₹ 51,397.50 |
PIPA577810 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 51,397.50
GST (18%): ₹ 9,251.55
Total Price: ₹ 60,649.05
Antigen
ULK1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ULK1
Gene Alias
APG1; ATG 1; ATG1; ATG1 autophagy related 1 homolog; ATG1A; AU041434; Autophagy-related protein 1 homolog; C. elegans; EC:2.7.11.1; FLJ38455; hATG1; KIAA0722; mKIAA0722; Serine/threonine-protein kinase ULK1; serine/threonine-protein kinase Unc51.1; ULK 1; Ulk1; UNC 51; UNC51; unc-51 like autophagy activating kinase 1; unc-51 like kinase 1; Unc51.1; unc-51-like kinase 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
22241, 360827, 8408
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
Gene Accession No.
O70405, O75385
Gene Symbols
ULK1
Immunogen
Synthetic peptide from the mid-protein of Human ULK1 (aa 567-577)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A 1:1,000 dilution of PA5-77810 was sufficient for detection of ULK1 in 15 μg of Human HeLa Cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.∣Detects approximately 100 kDa
- ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation
- The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein
- Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR
- ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy
- Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein
- ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.