PIPA568219
MED11 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA568219-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA568219 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
MED11
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MED11
Gene Alias
1110030J09Rik; AI465144; AW545069; HSPC296; MED11; Mediator complex subunit 11; mediator of RNA polymerase II transcription subunit 11; mediator of RNA polymerase II transcription, subunit 11 homolog; RGD1563202
Host Species
Rabbit
Purification Method
affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
287456, 400569, 66172
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q9D8C6, Q9P086
Gene Symbols
MED11
Immunogen
Synthesized peptide derived from human MED11.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Predicted to react with Human and Rat samples
- In mammalian cells, transcription is regulated in part by high molecular weight co-activating complexes that mediate signals between transcriptional activators and RNA polymerase II (Pol II)
- The mediator complex is one such multiprotein structure that functions as a bridge between regulatory proteins and Pol II, thereby regulating Pol II-dependent transcription
- Med11 (mediator complex subunit 11) is a 117 amino acid nuclear protein and component of the mediator complex
- The gene encoding Med11 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes
- Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1
- Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome
- Like p53, BRCA1 is directly involved in DNA repair, and is associated with predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.